The 1980–81 Football League season was Birmingham City Football Club's 78th in the Football League and their 46th in the First Division, to which they were promoted in 1979–80. They finished in 13th position in the 22-team division. They entered the 1980–81 FA Cup in the third round proper and lost to Coventry City in the fourth, and were eliminated in the quarter-final of the League Cup by Liverpool.
Twenty-three players made at least one appearance in nationally organised first-team competition, and there were eleven different goalscorers. Defenders Joe Gallagher and Dave Langan and midfielder Archie Gemmill each played in every game but one over the season, and Frank Worthington was the club's top scorer with 18 goals, of which 16 were scored in the league.